Dr. John Napoleon is assistant professor of biomedical sciences and a research scientist in the Department of Translational Science and Medicine at the College of Community Health Sciences. His research interests include targeted immuno-oncology, drug delivery, bispecific immune cell engagers and immune cell reprogramming in cancer and inflammatory diseases. His contributions to cancer research include the discovery of a selective MAP3K1 kinase inhibitor for pancreatic cancer treatment, the selective rejuvenation of exhausted chimeric antigen receptor T-cells in solid tumors, and the targeted polarization of tumor-associated macrophages and myeloid-derived suppressor cells within the tumor microenvironment. Napoleon has authored 20 articles published in international peer-reviewed journals and has filed nine patents (three issued, six pending). He received his doctorate in bio-organic and medicinal chemistry from the Institute of Technology Madras in India. Napoleon completed a postdoctoral study in cancer immunotherapy and targeted immune modulation at Purdue University in West Lafayette, Indiana. Prior to joining CCHS, he worked as an associate research scientist at Purdue University.
(205) 348-2441 jnapoleon@ua.edu
